Tries from Charles Ollivon and Damian Penaud condemned Ireland to a second straight defeat as France went top of the Six Nations table.
Ireland's Six Nations hopes are in tatters after they fell to a second successive defeat, a comeback attempt falling short in a 15-13 loss to France.
Andy Farrell's side were undone by an early red card for Peter O'Mahony against Wales, but it was their failure to capitalise in the 10 minutes when France were down to 14 that proved key this time around.
Charles Ollivon scored the first of two France tries while they were undermanned, giving the visitors an advantage they never surrendered.
They led 15-3 five minutes before the hour and, although a spirited revival gave Ireland hope, the hosts could not complete a turnaround, meaning their championship prospects are effectively over. France, by contrast, go into the first rest weekend top of the table.
Matthieu Jalibert and Billy Burns each missed early penalties before Burns knocked a simple one over to give Ireland a 3-0 lead.
The hosts were then boosted further when Bernard Le Roux was shown a yellow card for tripping during a kick-chase.
James Lowe looked to have taken an immediate advantage when he went over in the left corner but the TMO ruled he had been pushed into touch by the scrambling France defence.
Ireland were punished for not taking that chance in stunning fashion as a wonderful France attack, in which the ball was intricately worked to the right and then back left, ended with Gael Fickou sending Ollivon over.
Jallibert added the extras and landed a penalty shortly before the interval.
France wasted a golden opportunity to go further ahead following a superb carry from Julien Marchand before Ireland's task was made more difficult when Cian Healy and Iain Henderson clashed heads in a tackle.
Ed Byrne and Ultan Dillane entered the fray as replacements for their bloodied team-mates but could not help Ireland wrest control of the game away from France.
The visitors' command was strengthened in the 57th minute when Jallibert looped a long pass out to Brice Dulin, who shrugged off a defender and fed Damian Penaud for France's second try.
Yet Jallibert failed with the conversion and, after Ollivon was penalised from the kick-off, Ronan Kelleher marked his introduction by strolling over following a fortunate bounce at a line-out.
A long-range penalty from Ross Byrne trimmed the gap to two points and Jallibert failed to respond in kind nine minutes from time as he struck the upright from 51 metres.
But as in Cardiff last week, Ireland failed to produce a dramatic final say and will likely be playing for little more than pride for the rest of the tournament.
Ollivon helps France end Dublin bleus
Ollivon has become a talisman in the Six Nations, his five tries are the most in the competition since the start of last season.
His score on this occasion was worthy of great admiration and put France on course to win their first Six Nations match in Ireland since 2011 and claim back-to-back wins in this fixture for the first time since that triumph.
An unwanted first for Ireland
Ireland have always at least been in the mix after the first two weeks of the Six Nations. That is not the case this year, with Farrell leading them to consecutive defeats at the start of a campaign for the first time.
What's next?
After a week to reflect on a disappointing start, Ireland visit Rome to take on Italy in what looks like a wooden spoon decider at this juncture. The Azzurri have also lost two from two.
France welcome Scotland to Saint-Denis a day later, with two of their final three games in their bid for a first title since 2010 coming at the Stade de France.
