South Africa have won eight of 13 series against the British and Irish Lions, but it is a long time since they have triumphed back-to-back.
The British and Irish Lions will repeat a feat last achieved back in 1959 if they avoid a series defeat in South Africa.
Warren Gatland's side drew with New Zealand four years ago after a 2-1 triumph in Australia in 2013.
It is 62 years since the Lions were able to avoid defeat in a third consecutive tour and they will have to face the world champions without Alun Wyn Jones, who was replaced as captain by Conor Murray after he suffered a dislocated shoulder in the win over Japan.
Confirmation on Sunday that three members of the Springboks squad have tested positive for coronavirus was a concern before the Lions boarded the plane to South Africa.
They are due to play five tour matches before the first Test against the Springboks at Cape Town Stadium on July 24.
Stats Perform picks out some of the standout Opta numbers for such an eagerly-awaited tour.
BOKS TO GO BACK-TO-BACK?
South Africa were 2-1 winners the last time the Lions toured in 2009, but they have not won back-to-back series since coming out on top in 1962 and 1968.
The Springboks have won eight, lost four and tied one of their previous series against the Lions.
South Africa can boast 23 victories to the Lions' 17, with six of the 46 previous showdowns ending in a draw.
There have been alternate winners in the past five series between the Lions and South Africa, a sequence the Lions will be hoping continues.
SOUTH-AFRICA-BORN FLYER AMONG DEADLY DEBUTANTS
While the loss of Jones and Justin Tipuric to injury in the win over Japan at Murrayfield were big blows, Gatland will have been encouraged by the performances of his debutants.
Three of the four try-scorers in Edinburgh were making their Lions bows, with Josh Adams, Duhan Van Der Merwe and Tadhg Beirne crossing.
South-Africa born Scotland wing Van der Merwe was the leading try-scorer in the Six Nations this year with six and beat 31 defenders in the tournament, breaking a record set by Brian O'Driscoll.
He can make a big impact against his country of birth along with Adams, the leading try-scorer at the 2019 World Cup with seven.
South Africa must also be wary of Louis Rees-Zammit, the youngest tourist aged 20, after he scored four Six Nations tries and had the most clean breaks (nine) in the competition, also gaining the most metres per carry (9.9m from 27 carries).
Beirne caught the eye against Japan and can play a big part in South Africa. He affected the most turnovers in the Six Nations with nine and was the first man to 87 rucks - the same number as Gregory Alldritt.
PASS MASTER MURRAY CAN DICTATE
Murray was surprised to be given the honour of skippering the Lions in the absence of the most-capped player in the history of international rugby.
The Ireland scrum-half has vast experience and can lead by example in his third Lions tour.
Murray has won two, lost two and drawn one of his previous Lions Tests and will look to pull the strings for the tourists.
The 32-year-old pivot has assisted 25 Six Nations tries, eight more than any other player, and holds the record for the most passes in the competition with 3,527. Peter Stringer is next on the list with 2,539.
KEY MEN CAN ROAR AGAIN
There were some outstanding performances in the Lions' tour of New Zealand as they drew 1-1 with the All Blacks.
Maro Itoje was among the heroes of that tour and the England lock will embrace the battle with the Springboks. He hit more rucks (162) than any other player in the Six Nations this year and amassed 16 turnovers.
Versatile back Liam Williams made the most metres by a Lions player on the tour in New Zealand four years ago with 344 from six games.
Gatland has been able to rely on Taulupe Faletau time and again over the years. The back-row made the most tackles (76) in New Zealand and beat more defenders (14) than any other forward.