NSW Waratahs playmaker Ben Donaldson will start at flyhalf for the first time in Wallaby gold against Wales in Cardiff on Saturday afternoon (local time).
With a number of players unavailable following the three-point loss to world number one Ireland, Dave Rennie and the selection group has made seven changes to the starting XV.
Former Junior Wallaby, Donaldson will partner with club captain Jake Gordon who starts at scrumhalf for the side's final Test of 2022.
A new-look backrow sees Langi Gleeson also earn his first Test start at number eight in place of the injured Rob Valetini, while Fraser McReight comes in for Michael Hooper at openside flanker, with Jed Holloway rounding out the loose forward trio at blindside flanker.
James Slipper will lead the side as loosehead prop in his 127th appearance for his country, partnering with long-time Brumbies teammates Folau Fainga'a and Allan Alaalatoa in the front row.
The athletic Nick Frost will be looking to continue his breakout debut season at international level, starting at lock alongside workhorse Cadeyrn Neville for the fourth time this year.
Melbourne Rebels stalwart Reece Hodge will again showcase his incredible versatility, named at inside centre for the first time in the Test arena since 2016, partnering with Len Ikitau who will again wear the familiar number 13 jersey in the midfield.
After an impressive performance off the bench in Dublin, Jordan Petaia earns a start on the right wing, linking with Tom Wright who is selected at fullback, while Mark Nawaqanitawase completes the back three on the left edge.
Lachlan Lonergan has been named as the finishing hooker with Force front rower Tom Robertson the replacement loosehead while Rebels journeyman Sam Talakai is in line to become Wallaby number 963 after being selected for a potential debut off the pine as the tighthead cover.
Coonamble-raised Ned Hanigan returns to the game day squad with the versatile Pete Samu selected to cover the backrow, a role he has filled with great impact so far in 2022.
Queensland captain Tate McDermott returns to the side to provide spark as the replacement scrumhalf, while Noah Lolesio will be the finishing playmaker. Jock Campbell rounds out the matchday 23 as the back three cover.
The Wallabies are looking to win at Principality Stadium for the first time since 2017.
Every Wallabies Test from the 2022 Spring Tour will be ad-free, live and on-demand with extended coverage on Stan Sport.
Wallabies team to play Wales at Principality Stadium, Cardiff on Saturday 27 November, 3:15pm GMT/2:15am AEDT (Sunday)
1. James Slipper (c) (126 Tests)
2. Folau Fainga’a (37 Tests)
3. Allan Alaalatoa (63 Tests)
4. Nick Frost (8 Tests)
5. Cadeyrn Neville (7 Tests)
6. Jed Holloway (9 Tests)
7. Fraser McReight (9 Tests)
8. Langi Gleeson (2 Tests)
9. Jake Gordon (19 Tests)
10. Ben Donaldson (1 Test)
11. Mark Nawaqanitawase (2 Tests)
12. Reece Hodge (61 Tests)
13. Len Ikitau (25 Tests)
14. Jordan Petaia (24 Tests)
15. Tom Wright (22 Tests)
16. Lachlan Lonergan (7 Tests)
17. Tom Robertson (30 Tests)
18. Sam Talakai*
19. Ned Hanigan (27 Tests)
20. Pete Samu (32 Tests)
21. Tate McDermott (20 Tests)
22. Noah Lolesio (16 Tests)
23. Jock Campbell (3 Tests)
2022 Spring Tour Fixtures
Wallabies 16 defeated Scotland 15, Sunday 30 October at BT Murrayfield, Edinburgh
Wallabies 29 defeated by France 30, Sunday 6 November at Stade de France, Paris
Wallabies 27 defeated by Italy 28, Saturday 12 November, at Stadio Artemio Franchi, Florence
Wallabies 10 defeated by Ireland 13, Saturday 19 November at Aviva Stadium, Dublin
Wallabies v Wales, Sunday 27 November, 2:15am AEDT at Principality Stadium, Cardiff