France are the only side that can still complete the Six Nations Grand Slam, though they are sure to face a stern test from Scotland.
Scotland denied France glory in last year's Six Nations, with their dramatic victory in Paris meaning Les Bleus missed out on the title.
Now, France will be out for vengeance as they head to Edinburgh at the top of the standings with two victories from their opening two matches.
England, meanwhile, bounced back from their defeat to Scotland in round one with a hammering of Italy, and Eddie Jones' second-placed team host Wales at Twickenham.
Wales lost convincingly to Ireland in their first game, yet defeated Scotland 20-17 last time out, though the defending champions are down in fifth place as it stands.
The final match of the weekend sees Ireland take on Italy in Dublin. The Azzurri are staring down the barrel of a 100th Six Nations defeat.
Ahead of the third round of fixtures, Stats Perform previews each match with help from Opta.
SCOTLAND V FRANCE
FORM
Scotland have won four of their last six games against France in the Championship, including the last two in a row and a first win in Paris since 1999. They have not won three in a row against Les Bleus in the tournament since 1956-1958.
This will be the 99th meeting between Scotland and France in all competitions, with Les Bleus leading the head to head with 56 wins (L39, D3). However, honours are even across the last 10 clashes, with both sides picking up five wins each.
France opened their campaign with a pair of wins, something they also managed in 2021. The only time since 2011 when they have won their opening three games was in 2020, when they missed out on the title and a Grand Slam after a fourth-round defeat to Scotland at Murrayfield.
ONES TO WATCH
Darcy Graham has beaten a Championship-high nine defenders so far. He is just ahead of French duo Gabin Villiere, Damian Penaud, and Marcus Smith.
France's Gregory Alldritt has made more carries (30) than any other player, while he has also gained 83 post-contact metres, the most of any forward and fourth most of any player, after Ireland's Mack Hansen (107), Scotland's Graham (86) and team-mate Penaud (84), as well as hitting 10 more defensive rucks (36) than anyone else.
ENGLAND V WALES
FORM
The last four Six Nations matches between these sides have been won by the home side on the day. Indeed, England have won their last four home games against Wales in the Championship, only once since 1930 have they enjoyed a longer such streak, a nine-game run between 1990 and 2006.
England have lost just two of their last 24 home games in the Six Nations (W21, D1), defeats to Ireland in 2018 and Scotland in 2021. Wales' last win at Twickenham in the Championship was in 2012. Since the start of the 2016 tournament, Wales have picked up just one away victory outside of Scotland or Italy, a 24-19 win in Paris in 2019.
England (49) and Wales (34) have made more maul metres than any other sides so far in this edition of the Six Nations.
ONES TO WATCH
Jones has named Ben Youngs on England's bench. If he comes on, Youngs will win his 115th Test cap, overtaking Jason Leonard as the country's most capped men's player. The scrum-half has been involved in five tries in his last six starts against Wales (three tries, two assists).
Alex Cuthbert is set to play for Wales for a 50th time. He is looking to score his first try in the Six Nations since crossing against Italy in 2014.
IRELAND V ITALY
FORM
Ireland have won 21 of their 22 previous Six Nations matches against Italy, their sole defeat coming in 2013 (15-22), in what was the Azzurri's last home victory in the Championship.
Italy's next defeat will be their 100th in the Championship, they are currently on a record 34 match losing run, almost seven years since last claiming a victory (22-19 v Scotland, 28 Feb 2015).
Ireland hold a 100 per cent win rate against Italy at home in the Six Nations (W11), with the Azzurri the only side that has never won at the Aviva Stadium or Croke Park. Indeed, Ireland have scored 50 or more points in each of their last three home games against the tournament's whipping boys.
ONES TO WATCH
Hansen, Jamison Gibson-Park and Bundee Aki are three of just six players to both score and assist a try, the trio all scoring once and assisting one try after two rounds.
Italy's Federico Ruzza has won more lineouts (16) than any other player, including one steal, and team-mate Michele Lamaro has made the most tackles (41) in the tournament.
