England got off to a fast start in Rome as Ben Youngs scored a try in his 100th test appearance.
Youngs scored after a nice break by Owen Farrell with Farrell adding a further three points from the tee.
However, Italy managed to hit back with Jake Polledri tearing through the England defence to score an excellent try.
The chance game after Kyle Sinckler's pass didn't go to hand and Italy centre Carlo Canna pounced on the ball and sent Polledri on his way.
Pollderi burst through attempted tackles by Ben Youngs and Anthony Watson before beating Jamie George and rode Henry Slade's tackle to score out wide.