Six Nations: seven things to look out for this weekend

England’s replacements may prove key, while Wales are grappling with problems of their own making as Italy scent an upsetRob Howley increasingly cuts the figure of a man damned if he does and in a similar predicament if he does not. His team selection – Wales are unchanged from their defeat in Scotland – has been widely criticised but he does not have a huge amount of options at his disposal. That, however, is the crux of the problem. Wales are fearful of finishing the tournament with two defeats that could well mean they slip out of the top eight in the world and face another treacherous Worl…