Six Nations: Sergio Parisse Sets New Six Nations Record
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Sergio Parisse will set a new Six Nations record when he runs out for his 66th appearance in the competition, a record he currently shares with former Ireland captain Brian O'Driscoll.
Another milestone will be reached at Murrayfield against Scotland with Leonardo Ghiraldini earning his 100th test cap.
Second rower David Sisi will make his test and will be the twenty-sixth player to earn his debut under Conor O'Shea.
Italy team to face Scotland